EFFECTS OF A PYRROLIZIDINE ALKALOID, INTEGERRIMINE, ON MOUSE SPERM MORPHOLOGY
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Abstract
The pyrrolizidine alkaloid (PA), integerrimine, a natural product obtained from Senecio brasiliensis, was used at single dose, in two concentrations (18.75 or 37.5 ing/kg) to test its ability to induce morphological abnormalities in spermatozoa of inbred C57BL/6 mice. The anomalies were classified in nine types, six of which presented anomalous sperm heads. The frequency of three types of anomalous sperm heads were increased by integerrimine at the higher dose level, and only one at the lower dose level. The results suggest that integerrimine can modify, at least in part, some step of spermatogenesis
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